I hope that with increased knowledge we will all find the right road. [5]Wawrzynska L, Sakowicz A, Rudzinski P, Langfort R, Kurzyna M: The conversion to triiodothyronine in the lung: comparison of activity of type I iodotironine 5 deiodinase in lung cancer with peripheral lung tissues. However, I'm learning from science writer friends, researchers, and medical professionals that (1) some studies are better designed and carried out than others, and (2) some journalists are more careful about drawing conclusions and writing sensational headlines than others. The Goji Berry: The Jolly Super Food That Gives Yo How to Prevent and Treat Insect Bites Without Hars Supreme Court Rules Drug Companies Exempt From Law Spain Study Confirms Hemp Oil Cures Cancer without Wheatgrass Turns Gray Hair Back to Its Natural Color, Medicinal Cannabis Used To Prevent Cancer Growth. I am just as much in the dark as some others on this site. [7] They also elaborate on a mechanism of T4-induced lung tissue toxicity: [I]n rats lung the deiodination of LT4 is the lowest compared to all the other tissues. An Italian study published in the journalReproductive Biology and Endocrinology,titled Levothyroxine and lung cancer in females: the importance of oxidative stress, has raised a concerning possibility: levothyroxine (T4), one of the worlds most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low thyroid function (hypothyroidism). [7] They also elaborate on a mechanism of T4-induced lung tissue toxicity: "[I]n rats lung the deiodination of LT4 is the lowest compared to all the other tissues. Sub-laboratory hypothyroidism and the empirical use of Armour thyroid.Altern Med Rev. In 2011 I switched docs and was put on Armour as he told me Synthroid and the like are poison and they do not work. Finally, they pointed out that T4, which is a synthetic form of thyroid hormone, might be avoided if T3 or the desiccated pig-derived form known as Armour Thyroid was used to control the oxidative-stress producing hydroperoxides. This discussion has been closed to comments. At GreenMedInfo.com, we have indexed plenty of peer-reviewed research on over 30 natural substances, including nutrients and minerals, which may help to resolve low thyroid function, and conversely, over 30 unnatural substances, e.g. El almacenamiento o acceso tcnico que se utiliza exclusivamente con fines estadsticos annimos. Ultimately, this Italian study brings further attention to one of a wide range of unintended, adverse health effects associated with the overdiagnosis and subsequent overtreatment of hypothyroidism, and the underlying failure of the conventional, largely drug-based paradigm to comprehend the causes and real solutions of disease and human suffering. 2004 Jun;9(2):157-79. But that's just me. Why not simply call it selenium deficiency? Those with the greatest risk of developing thyroid disorders are women who have a family history of the disease. Data sources: The Medline and Cochrane Library electronic databases . They only reappear when I need to fine tune the medication. Are you sure you want to block this member? elevated TSH, without actually improving the overall physiological situation, nor the patient's subjective experience of well being. A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.' LOL. Other factors that can trigger thyroid problems include: autoimmune diseases like Hashimoto's or Graves' disease; thyroid surgery; radiation treatments to the neck or upper chest; and certain medications, including interferon alpha and interleukin-2 cancer medications, amiodarone . [learn more: Is Drug-Based Medicine a Form of Human Sacrifice?] 1 The number of individuals with thyroid disorders is expected to continue to grow, having reached approximately 750 million globally in 2012. Link posted. [11] Wan J, Chai H, Yu Z, Ge W, Kang N, Xia W, Che Y: H1F-1 on angiogenic potential in human small cell carcinoma. At GreenMedInfo.com, we have indexed plenty of peer-reviewed research on over 30 natural substances, including nutrients and minerals, which may help to resolve low thyroid function, and conversely, over 30 unnatural substances, e.g. I have posted the link, so you can see if it has any merit. JavaScript is disabled. For more information, please see our Monaldi Arch Chest Dis 2003, 59:140145. Acta Endocrinol 1988, 118:460464. CRF encompasses physical, emotional, and/or cognitive tiredness; is related to cancer or cancer treatments; and interferes with multiple dimensions of health-related quality of life (1-3).CRF is poorly understood, underrecognized, and undertreated. undefined will no longer be visible to you including posts, replies, and photos. In addition, untreated hypothyroidism is associated with a gradual decline in cognitive function and memory. I honestly do not know. The omnipresent environmental contaminant perchlorate, an ingredient in jet fuel, is also a primary cause of hypothyroidism, but is almost never tested for by the conventional endocrinologists in their patient evaluations. I discovered this article published in Wakeup World. They compared sale of, "However, the impression we get from our experience, Health, Studies, Supps & Pharmaceuticals. 2002 Feb ;25(2):106-9. Endocrinology 1985, 117:12011208. There is also the very real possibility that T4 will not only not properly interact with thyroxine cellular receptors, but will block out what remaining natural levothyroxine the thyroid is still producing (and whose conformational state is far more health-promoting), essentially acting as an endocrine disrupter at the very moment that it is acting as intended as a TSH suppressor. This T4 blocking/endocrine-disrupting property of the synthetic form would also activate a negative feedback loop within the endocrine system, further suppressing remaining thyroid function, and resulting in the atrophy of the compromised thyroid, a iatrogenic self-fulfilling prophecy if you will. weight loss, anorexia) was made many years ago together with an over production of both T4 and T3. Si as lo deseas puedes revisar el resto de nuestros contenidos para encontrar lo que buscabas o directamente utilizar nuestro buscador. This is a news report of the research, so I can't learn the details of how the science was conducted. Find how some diseases can be healed with alternative medicine, and share your experience with International Journal of Human Nutrition and Functional Medicine, Black Seed May Treat Hypothyroidism (Hashimotos Disease), Clinical Trial Reveals, Wi-Fi Devices Increase Mercury Release From Dental Amalgams, Participating in Drum Circles Improves Health and Quality of Life in Parkinsons Patients (Study), Acupuncture Beats Injected Morphine for Pain: Groundbreaking Study, Mammography Is Harmful and Should Be Abandoned, Scientific Review Concludes, Killer Germs Obliterated by Medicinal Smoke Smudging, Study Reveals, Turmerics Smart Kill Properties Put Chemo & Radiation To Shame, Beet Juice Boosts Cognitive Function In One Dose, 13 Evidence-Based Medicinal Properties of Coconut Oil, Group Drumming Better Than Prozac, Study Suggests, 25 Cancer Stem-Cell Killing Foods That Are Smarter Than Chemo and Radiation, Ibuprofen Can Stop Your Heart 31% Increase in Cardiac Arrest Risk, Conscious Shopping Offering Conscious Products for Conscious People, Uncovering The Truths And Myths About 3 Superstar Herbs, Living Past 100: The Okinawan Diet and Blue Zone Centenarians, Repairs DNA and Rejuvenates Your Cells While You Relax, Why Daily Greens are the Real Fountain of Youth, T4 has been reported as one of the several endogenous factors capable of supporting proliferation of lung cancer cells. I have so much to say about this I could write a book. [11] Wan J, Chai H, Yu Z, Ge W, Kang N, Xia W, Che Y: H1F-1 on angiogenic potential in human small cell carcinoma. In comparison, 62.4% of female and 37% of male . However, that information will still be included in details such as numbers of replies. [3]Faber J, Poulsen S, Iversen P, Kirkegaard C: Thyroid hormone turnover in patients with small cell carcinoma of the lung. Here members can share stories, find important information and learn from the experiences of others like themselves. I bet in the previous discussion, if there was one, we would have concluded it was likely that it was because people are generally not put on enough levothyroxine. In fact, a 2004 study in subjects with normal thyroid function found that administration of tyrosine leads to a significant reduction in serum TSH and improvement in mood in winter compared with placebo, while the combined synthetic T4-T3 supplement leads to a worsening of mood in summer and no improvement in winter, indicating supporting glandular function is superior to replacement therapy, as well as the role seasonality may play in hormone function and hormone treatment interventions. Lung cancer survivors support group and discussion community, http://www.greenmedinfo.com/blog/study-millions-treated-hypothyroidism-risk-lung-cancers?utm_source=www.GreenMedInfo.com&utm_campaign=2189ddd3c1-Greenmedinfo&utm_medium=email&utm_term=0_193c8492fb-2189ddd3c1-87046221. [14] In other words, you can normalize the main clinically measurable parameter associated with low thyroid function, i.e. There is evidence T4 makes cancer more agressive, so although it increases the risk of cancer the mortality risk is higher. [14] In other words, you can 'normalize' the main clinically measurable parameter associated with 'low thyroid function,' i.e. weight loss, anorexia) was made many years ago together with an over production of both T4 and T3. ", Cure Alveolar Soft Part Sarcoma International, COMPLETED - Dana Farber Vaccine Clinical Trial (GVAX), Axitinib and Pembrolizumab (Keytruda) in Miami, US, TECENTRIQ (atezolizumab) by Genentech, Treatment of Non-Resectable Primary Tumor, Immune checkpoint inhibitors ICI (PD-1 and PD-L1 targeting drugs), Toxicity, problems and potentiation strategies, Treatment response criteria and evaluation/scanning problems/rare cases, treatment discontinuation/re-treatment, Side effects/complications of the local ablations, High intensity focused ultrasound (HIFU), Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer, http://www.greenmedinfo.com/blog/study- ng-cancers. Indeed, research indicates that hypothyroid patients treated with T4 replacement, that is sufficient to maintain a normal serum TSH, actually have serum free T4 that is higher than in untreated normal patients and may not result in appropriately normal serum free T3 concentrations. It's possible, for instance, that the reason both sales of Synthroid and the incidence of lung cancer increased is due to an environmental condition that affected both the thyroid and the lungs. I don't believe there are thousands of people on to high a dose of t4, so why does it feel they are hyper? In the U.S., the overall five-year survival rate for patients diagnosed with lung cancer is 25%, which is a 21% improvement over the . The authors of the study pointed out that levothyroxine (T4) treatment can lead to medication-induced (iatrogenic) thyroid over-activity (hyperthyroidism) and oxidative stress that can lead to a significant patient discomfort. PMID 11836274. [2] Meng R, Tang HY, Westfall J, London D, Cao JH, Mousa SA, Luidens M, Hercbergs A, Davis FB, Davis PJ, et al: Crosstalk between integrin v3 and estrogen receptor- is involved in thyroid hormone-induced proliferation in human lung carcinoma cells. When a high-risk patient presents with one or more lung nodules, the path ahead and next steps seems obvious. Factors found to be associated with mortality were age, senile dementia, congestive heart failure, chronic renal failure, and a history of cerebrovascular disease. If you are already a member, please, Levothyroxine and lung cancer in females: the importance of oxidative stress, recent announcement by a National Cancer Institute, T-score based definition of osteoporosis and osteopenia, 30-billion dollar a year market in statin drugs. The reality is that most cases of hypothyroidism today are diagnosed in populations who are experiencing a combination of basic nutritional deficiencies and chemical exposures, or who are simply going through a temporary down-cycle in thyroid function following a natural change, such as the natural postpartum drop that occurs in women after giving birth. The Flu Propaganda Matrix Continues To Promote Fea B Vitamins Slow Alzheimer's and Grey Matter Loss. The study included more than 128,000 veterans aged 18 to 26 and found that, just 30.2% of females and 18.7% of males had received HPV vaccination. I wish I could say that my story was atypical. Forgot account? Obesity epidemic caused by EMF exposures in the ho War on Health - The FDA's Cult of Tyranny. Different strokes for different folks for sure! For a better experience, please enable JavaScript in your browser before proceeding. You may not notice signs or symptoms of the disease. Patient characteristics. It was the therapist that I went to that referred me to a specialist who ran the correct tests. They then correlated drug sales with cancers, eliminating the contribution of age and smoking for lung cancer risk. If I can help someone, fine. PLoSone 2011, 11:e27547. The aim of the study was to assess the occurrence and nature of immune-related endocrine adverse events (irAEs) among patients with non-small-cell lung cancer (NSCLC) treated with nivolumab. Symptoms can include fatigue, shortness of breath with exercise, and decreased ability to exercise. See more of Keri Topouzian, D.O. ', Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer. Is that what releases free radicals? Overtreatment, of course, is the hallmark danger of overdiagnosis. A place for patients and relatives. One of the main drawbacks of administering T4 in isolation is the possibility that it will not convert adequately to T3, and will therefore 'back up' causing excessive T4 activity, i.e. Intuition and Trust: a Personal Journey Through Ancient Pathways, Meditation, Yoga, Grounding & Mindfulness, Levothyroxine and lung cancer in females: the importance of oxidative stress, 2013 announcement by a National Cancer Institute, T-score based definition of osteoporosis and osteopenia, 30-billion dollar a year market in statin drugs, Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). Symptoms. Due to excessive bot signups along with nefarious actors we are limiting forum registration. I am convinced that my lung cancer is related to the thyroid/auto immune issues I've had for years. The study looked at the prevalence of breast, colorectal, gastric and lung cancer in 18 Italian Regions during 2010 and correlated this data with sales of LT4 in 2009, focusing on women aged 30-84. A couple of caveats to note in this study: The authors found a statistical correlation between the increase in sales of the thyroid medicine Synthroid, and an increase in lung cancer in Italy. Sin un requerimiento, el cumplimiento voluntario por parte de tu Proveedor de servicios de Internet, o los registros adicionales de un tercero, la informacin almacenada o recuperada slo para este propsito no se puede utilizar para identificarte. Is This the Real Reason You're Exhausted All the T Why An Alkaline Approach Can Successfully Treat Ca We're Losing the War on Cancer- Here's Why. The study looked at the prevalence of breast, colorectal, gastric and lung cancer in 18 Italian Regions during 2010 and correlated this data with sales of LT4 in 2009, focusing on women aged 30-84. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. If the results show that TSH is high and T-4 is low, then the diagnosis . Whether it should be treated remains controversial. Just for entertainment value take a look at some more dodgy correlations : I rather liked the correlation between consumption of orange marmalade and birth rate - in the years after the second world war if I remember correctly. Untreated hypothyroidism increases morbidity and mortality. Results indicate that treatment with levothyroxine was linked with significantly increased mortality (hazard ratio = 1.19). http://www.greenmedinfo.com/blog/study-millions-treated-hypothyroidism-risk-l Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer, Iodine Supplementation Support by VWT Team. The omnipresent environmental contaminant perchlorate, an ingredient in jet fuel, is also a primary cause of hypothyroidism, but is almost never tested for by the conventional endocrinologists in their patient evaluations. Nope. If You Don't Want Older Bones, Don't Be Low In Vit Background Mortality Rate for Vaccines, or Pseudo Everything You Ever Wanted to Know About Black Seeds. If people do not wish to find out all they can about their disease that is fine too. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. 2013 May ;98(5):1982-90. [4], More recently DI activity in lung cancer was found to be lower than in peripheral lung tissue.[5]. Nanosized aluminum being sprayed in the atmosphere CDC Admits as Many as 30 Million Americans Could b Why Turmeric May Be the Diseased Liver's Best Friend. (February 2002). The authors expanded on their findings further: However, the impression we get from our experience in epidemiological studies monitoring[12] is that this drug should be prescribed more cautiously. 'A new Italian study published in the journal Reproductive Biology and Endocrinology titled, "Levothyroxine and lung cancer in females: the importance of oxidative stress," has raised a concerning possibility: levothyroxine (T4), one of the world's most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low thyroid function (hypothyroidism). The first blood test typically done to diagnose hypothyroidism measures the level of thyroid-stimulating hormone (TSH) in the blood. Whereas a patient who had suboptimal thyroid function, but did not have noticeable symptoms, is suddenly given pharmacological doses of synthetic T4 and suddenly experiences the wide range of acute, adverse health effects associated with a now hyperactive and/or increasingly disrupted thyroid, as a result. BUT, this is the first I have heard of the potential risk of lung cancer in those who take Synthyroid. Given the clear role that selenium deficiency plays in preventing the conversion of T4 to the far more biologically active form of thyroid hormone known as triiodothyronine (T3), which can cause an elevation of thyroxine-stimulating hormone (TSH), why call a mineral deficiency-induced decrease in T4 a monolithic disease entity such as "hypothyroidism"? [6] Venditti P, Di Stefano L, Di Meo S: Oxidative stress in cold induced hyperthyroid state. Considering that the population in Italy is about 60 million people and the sales of LT4 in the country in 2010 were 17.69 million boxes (+ 6% Vs 2009), hypothyroidism, which is the main reason for the prescription, should be a real national concern (almost 0.7 boxes/women/year). People read a study and think that someone like, perhaps me, is saying "it Causes lung cancer. Join the forum, it's quick and easy . [1] Hercbergs AH, Ashur-Fabian O, Garfield D: Thyroid hormone and cancer: clinical studies of hypothyroidism in oncology. Other research indicating that increased thyroid activity (hyperthyroidism) contributes to lung cancer pathogenesis was presented, including: The authors also cite animal experimental research which has shown that T4 increases the oxidative stress[6] and spontaneous pulmonary metastases in mice.
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